Moreover, the inhibition of Orai1 by selective inhibitors, GSK-7975A and CM-128 by CalciMedica, markedly impaired the extracellular Ca2+ influx and sustained Ca2+ overload in pancreatic acinar cells upon bile acid stimulation, significantly reducing pancreatic edema, inflammation and necrosis in experimental models of AP [83]. Here, ORAI1 is linked to alkaline phosphatase measurement.