NFKB1 and alkaline phosphatase measurement: Using CM4620, another selective Orai1 channel blocker by CalciMedica, Waldron et al. demonstrated that the inhibition of SOCE prevents trypsinogen activation, acinar cell death, NF-κB and nuclear factor of activated T-cells (NFAT) activation, inflammatory responses in in vitro models, and decreases the severity of experimental AP in mice [84].