NFE2L2 and cancer: Other molecular signaling pathways such as the Wnt signaling pathway [38,100], phosphoinositide 3-kinase-related protein kinase (PI3K) [77], nuclear factor erythroid 2-related factor 2 (Nrf2) [101], and sirtuin 1 (SIRT1) [102] may also be involved in the resistance of cancer cells to CP therapy.