Ang II/ATR1 pathway activation has been shown to promote EMT in cancer cells, which is a hallmark of cancer aggressiveness [76], while chymase, a protease that converts Ang I to Ang II, increased the expression of MMP-9 in a dose dependent manner in two lung cancer cell lines (A549 and H520) [30]. The gene discussed is MMP9; the disease is lung carcinoma.