Recent data from a breast cancer model revealed an additional mechanism whereby ATR1 promotes tumor cell contraction, migration and invasion by upregulating the C-X-C chemokine receptor type 4 (CXCR4)/Stromal cell derived factor-1α (SDF-1α) signaling through the Focal adhesion kinase (FAK)/Ras homolog family member A (RhoA)/Rho associated kinase 1/2 (ROCK1/2)/Myosin light-chain kinase (MLC) pathway, ultimately inducing metastatic disease [78]. Here, RHOA is linked to breast carcinoma.