A study on T-ALL with t(5;14)(q35;q32.2) highlights the involvement of HMGA1 in the mechanism of dysregulation of TLX3 or NKX2-5 homeobox genes as a consequence of 5q35 juxtaposition with 14q32.2 breakpoints dispersed across the BCL11B downstream genomic desert [210]. The gene discussed is HMGA1; the disease is acute lymphoblastic leukemia.