HMGA2 and myeloproliferative neoplasm: In their 2011 study, Ikeda et al. [129] created a HMGA transgenic mouse with 3′-UTR deletion and therefore overexpression of the HMGA2 mRNA (ΔHMGA2 mouse); a similar genetic alteration had already been observed in MPN [70,73,121,122,123,124,125].