We have found that (i) Morus fruit samples were rich in phenolics, anthocyanidin (cyanidin) and anthocyanins (kuromanin and keracyanin), (ii) aqueous Morus fruit extracts are involved in anti-oxidative stress, both in single electron transfer (SET) and hydrogen atom transfer (HAT) mechanisms, (iii) aqueous Morus fruit extracts exhibited strong inhibitory activities against AD key enzymes (AChE, BChE and BACE-1), and (vi) Morus sp. Here, ACHE is linked to Alzheimer disease.