ESR1 and breast cancer: The expression of many cell cycle-related genes was strongly hampered by DSCAM-AS1 silencing, including MYC proto-oncogene, bHLH transcription factor (MYC), a key regulator of cell growth, proliferation, and apoptosis [36], ret proto-oncogene (RET), a well-known proto-oncogene which regulates cell proliferation and survival and a direct target of the ERα signaling pathway [37], Topoisomerase II alpha (TOP2A), a proliferation marker whose higher expression in BC is associated with higher tumor grade and the Ki67 index [38].