Snail is a family of transcription factors that promote the repression of the adhesion molecule, E-cadherin, to regulate epithelial to mesenchymal transition (EMT) during embryonic development.miR-328 was down-regulated in stem-like side population (SP) cells in CRC, while an overexpression of miR-328 resulted in the inhibition of SP cells [76]. The gene discussed is SNAI1; the disease is colorectal carcinoma.