Furthermore, results from large number of patients with CRC suggested that high expression of YAP1, TEA domain family member 2(TEAD2) and YAP1 target genes cysteine-rich angiogenic inducer 61 (CYR61) and ankyrin repeat domain 1 (ANKRD1) were associated with a high risk of cancer relapse [2]. This evidence concerns the gene CCN1 and cancer.