CYP2J2 and cardiac hypertrophy: Cytochrome P450 2J2 (CYP2J2) is an epoxygenase enzyme that mediates the formation of epoxyeicosatrienoic acids (EETs) [199], and overexpression of this enzyme in mouse hearts suppresses cardiac hypertrophy and increases levels of atrial natriuretic peptide (ANP) [200].