BDNF and nervous system disorder: With regard to the qualitative effect of malnutrition on the brain, Edlow et al. showed that differences in the relative deficiency in micronutrients including minerals, vitamins, and amino acids provoked differential expression of more than 1000 genes in the mice embryonic brain, such as brain-derived neurotrophic factor (BDNF) and Kruppel-like factor 3 (KLF3), a transcription regulator linked to various neurological disorders [20].