Leppilahti et al. found that the MMP-8 and MPO levels in GCF showed large AUC values for the diagnosis of chronic periodontitis, of 0.90 and 0.98, respectively, with cutoff values of 2520.6 ng/mL and 135.9 ng/mL, which produced sensitivities and specificities of around 0.9 [13]. This evidence concerns the gene MMP8 and chronic periodontitis.