MMP8 and periodontal disorder: Previous studies have suggested the following possible biomarkers for periodontal disease: matrix metalloproteinase (MMP)-8, MMP-9, lactoferrin, cystatin C, myeloperoxidase (MPO), platelet-activating factor (PAF), cathepsin B, and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) [11,12,13,14,15].