Previous studies revealed that imidazole-based H3R antagonists, namely clobenpropit and ciproxifan, mitigated several oxidative stress markers (e.g., MDA and GSH) in amphetamine- or dizocilpine-augmented oxidative stress in a preclinical mice model of schizophrenia, signifying the protective effects of H3R antagonists in such conditions [86,87]. Here, HRH3 is linked to schizophrenia.