However, the H3R agonist RAM abrogated the effects provided by E100, demonstrating that E100 may exerted its effects on anxiety-like behaviors VPA mice through modulation of several other neurotransmitters, such as serotonin [80,81], glutamate, and GABA [82,83,84], that are reported to be imbalanced in ASD patients. The gene discussed is HRH3; the disease is Anxiety.