Given that Malat1 knockout mice are healthy and fertile, MALAT1 targeting in cancer can be a potentially viable mechanism to evade the emergence of a drug resistant phenotype in MALAT1 elevated chemo-resistant cancers or to achieve a significant anti-tumor and anti-metastatic effect in MALAT1 overexpressing cancers without causing any adverse side effects to healthy tissues. This evidence concerns the gene MALAT1 and cancer.