DHTKD1 and infection: To determine the physiological relevance of the 13S encoded E1A isoform on cellular metabolic reprogramming in the context of infection, in contrast to the 12S encoded isoform, IMR-90 primary lung fibroblast cells were grown to confluence for 72 h and infected with mutant HAdV-5 expressing either the 13S or 12S E1A isoforms.