To reinforce our data regarding the involvement of RKIP in melanoma cell motility, MeWO and A2058 metastatic melanoma cell lines were transfected with a RKIP-overexpressing plasmid resulting in a 5- and 15-fold increase of RKIP-mRNA level, respectively (Figure 4a). Here, PEBP1 is linked to metastatic melanoma.