KDM1A and central nervous system cancer: Another study showed that GSK3β phosphorylates lysine-specific histone demethylase 1A (KDM1A), allowing stabilization by ubiquitin-specific peptidase (USP)22 and thereby repressing the transcription of BMP2, CDKN1A and GATA6, and ultimately resulting in the self-renewal of glioma SCs [117].