RUNX1 and acute myeloid leukemia: For example, AML with RUNX1-RUNX1T1 (t(8;21)) shows a classical expression of CD34 and CD117, alongside CD13, CD33, and MPO, as well as evidence of neutrophilic maturation with some expression of CD15 and/or CD65; often there is aberrant expression of CD19 [17].