Previous studies have shown that inoculation of AD brain tissue extracts could be used for experimental induction of Aβ plaques and cerebral beta-amyloid angiopathy in non-human primates [95] and transgenic APP mice [96,97], although inoculation of preformed purified and synthetic fibrils from Aβ40/42 was less effective [98,99]. Here, APP is linked to Alzheimer disease.