Although osteoblasts having strong immune response displayed no significant difference by minor HLA DPB1 in immune rejection, we cannot still rule out that other alleles or DPB1 from HLA-II of lineage cells may occur strong immune rejection, such as graft-versus-host disease (GVHD) (Morishima et al., 2018). Here, HLA-DPB1 is linked to graft versus host disease.