PRKDC and neoplasm: When performing transcriptome analysis we found that, compared to the PRKDC wild‐type, the patients with PRKDC mutations tend to have an inflamed tumor microenvironment (TME) that includes higher numbers of CD8+ T cells, NK cells, Th1, and pDCs, and higher PD‐L1 expression, other immune checkpoints, and chemokine expression.