PRKDC and colorectal adenocarcinoma: The TMB levels of the top quartile are commonly considered TMB‐high [29], and according to the cutoff value, we found that 96% of PRKDC mutation samples were TMB‐H in the uterine corpus endometrial carcinoma cohort, followed by 82% of the PRKDC mutation samples being TMB‐H in the colorectal adenocarcinoma cohort and 81% in the gastric adenocarcinoma group (Fig. 2C).