In the Lander's endometrial carcinoma cohort [20, 21, 22], the TMB of the PRKDC mut+ samples is significantly higher than in the PRKDC mut− samples in both MSI‐H and MSI‐L/MSS subtypes (median nonsynonymous mutations 558 vs. 220, P < 0.001 in MSI‐H subgroup, 5764 vs. 31, P < 0.0001 in MSS/MSI‐L subgroup). Here, PRKDC is linked to endometrial carcinoma.