PRKDC and colorectal adenocarcinoma: In the TCGA cohort, colorectal adenocarcinoma had the highest PRKDC mutation frequency of 9.66% (51/528), followed by gastric adenocarcinoma with 9.63% (42/436), endometrial cancer 9.27% (23/248), and non‐small‐cell lung cancer 7.86% (81/1031; Fig. 1A) In the Geneplus cohort, melanoma had the highest mutation frequency of 5.88% (1/17), followed by small‐cell lung cancer with 5.45% (3/55) and cervical squamous cell carcinoma 3.33% (1/30; Fig. 1A).