SMARCA1 and cervical carcinoma: To evaluate the function of SWI/SNF chromatin remodeling complex in maintaining genome stability, BRM, a key ATPase subunit in SWI/SNF complex, was depleted by siRNAs in immortalized fibroblast VA13 cells and human cervical cancer HeLa cells, representing ALT (Alternative lengthening of Telomeres) and telomerase positive cells, respectively (Fig 1A).