To evaluate the function of SWI/SNF chromatin remodeling complex in maintaining genome stability, BRM, a key ATPase subunit in SWI/SNF complex, was depleted by siRNAs in immortalized fibroblast VA13 cells and human cervical cancer HeLa cells, representing ALT (Alternative lengthening of Telomeres) and telomerase positive cells, respectively (Fig 1A). The gene discussed is SMARCA2; the disease is cervical carcinoma.