Using a robust transgenic model our data clearly shows that the GDF15 mediated protection from growth of the PCa that develops spontaneously in C57/BL6 TRAMP mice, is dependent on intact adaptive immunity and in mice with adoptively transferred TRAMP tumors this response is at least in part mediated by CD8 bearing cells that are almost certainly T cells. This evidence concerns the gene GDF15 and posterior cortical atrophy.