The adjusted HR for incident peripheral vascular disease comparing SGLT2’i vs. DPP-4i’s, GLP-1a’s, and all non-SGLT2i AHAs, respectively, were 0.88 (95% CI 0.79–0.96), 0.95 (95% CI 0.84–1.07), and 1.11 95% CI (1.02–1.22), and for venous ulceration 1.12 (95% CI 0.91–1.39), 0.97 (95% CI 0.75–1.26), and 1.34 (95% CI 1.10–1.61). This evidence concerns the gene SLC5A2 and peripheral vascular disease.