Human tissues from T2D patients and non-T2D donors were examined to distinguish the differences of DNA methylation and expressions, such as pancreatic islets,[9–12] skeletal muscle,[13,14] liver,[15] and adipose tissue.[16] Dozens of relevant genes were observed differentially methylated and identified changes with impaired β-cell function, insulin secretion, impact on lipogenesis and adipokine secretion, insulin sensitivity. The gene discussed is INS; the disease is type 2 diabetes mellitus.