Overall survival rates of patients with HCC were significantly affected by Child-Pugh B (HR: 2.406 (1.117–5.181); P = .025), pre-sarcopenia patients (HR: 2.338 (1.232–4.436); P = .009), high grade of albumin to bilirubin grade (HR: 2.074 (1.132–3.798); P = .018), a-fetoprotein > 20 (HR: 2.027 (1.166–3.697); P = .013) according to univariate analysis. The gene discussed is ALB; the disease is sarcopenia.