ACE2 and cardiac hypertrophy: However, after infection with coronavirus, ACE2 and Ang(1–7) seem to have a protective effect on the pulmonary (reducing the severity of respiratory distress, pulmonary fibrosis, vascular leakage and pulmonary edema) and cardiac (reduction of cardiac injury, fibrosis, inhibition of cardiac hypertrophy and a reduction in the time of development of heart failure from cardiac hypertrophy in animal models) systems [3,7,9,13].