For instance, haploinsufficiency of catenin delta 1 (CTNND2; OMIM *604275) and semaphorin 5A (SEMA5A; OMIM *609297) in 5p have linked to severe intellectual disability in individual affected with CdCS (Correa et al., 2019; Medina, Marinescu, Overhauser, & Kosik, 2000; Nguyen et al., 2015). The gene discussed is SEMA5A; the disease is Intellectual disability.