According to the degree value, the top five hub genes extracted from the hypothyroidism group were ALB (albumin), MARK1 (microtubule affinity regulating kinase 1), SPP1 (secreted phosphoprotein 1), PPARG (peroxisome-proliferator activated receptor gamma) and MIF (macrophage migration inhibitory factor). This evidence concerns the gene MIF and hypothyroidism.