S-588410 is a novel CPV comprising five human leukocyte antigens (HLA)-A*24:02-restricted 9–10-mer peptides derived from five cancer testis antigens (DEPDC1, MPHOSPH1, URLC10, CDCA1 and KOC1), all of which have been found to be upregulated in esophageal cancer [11, 12]. This evidence concerns the gene LY6K and esophageal cancer.