Others have shown that BIN1 over-expression in mice causes microstructural changes in hippocampal circuits (Daudin et al., 2018) that are among the first to show tau pathology in Alzheimer’s disease (Daudin et al., 2018), suggesting that BIN1 may affect the development of Alzheimer’s disease by modulating tau effects at synapses, and possibly also synaptic activity-dependent tau release (Pooler et al., 2013). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.