In total brain homogenates, we confirmed a trend towards reduction in BIN1 in severe relative to moderate stage Alzheimer’s disease and control tissues (Fig. 1A and B) and significant increases in total and phosphorylated tau amounts with increasing disease severity (Fig. 1A, C and D), as previously reported (Kurbatskaya et al., 2016). The gene discussed is BIN1; the disease is Alzheimer disease.