The eQTL analysis by the GTEx Portal indicates that rs1800469 is an eQTL for multiple nearby genes, including TGFB1, B9D2 and TMEM91, in different tissues (Supplementary Table S1; https://www.gtexportal.org/home/), suggesting that rs1800469 affects the expression of such nearby genes and in turn influences the pathogenesis of asthma, CF and COPD; however, this analysis does not provide the molecular mechanism by which rs1800469 affects the expression of the genes. The gene discussed is TGFB1; the disease is chronic obstructive pulmonary disease.