CHI3L1 and asthma: They also reported the differential DNA methylation of genomic regions of three genes previously associated with asthma: TNIP-1 (TNFAIP3 interacting protein 1), IL-13, and CHI3L1 (chitinase 3 like 1) (29–31), showing that the nasal methylome may serve as a reliable biomarker of asthma in children.