TP53 and Miyoshi myopathy: The further functional assays were performed on the compound NSC622608, which was demonstrated to cause MM cell death through the modulation of TP53 signature, with the upregulation of the P53 dependent P21, NOXA, and PUMA proteins, the upregulation of MT1H, HMOX1, and ANXA2 genes and the reduction of POLD2, MCM5, MCM4, MCM3, MCM2, KIAA0101, and CCNA2 genes.