ALKBH5 belongs to the non-heme Fe(ii)- and α-ketoglutarate (KG)-dependent dioxygenase AlkB family of proteins demethylated NANOG mRNA, and stimulated the expressions of HIF-1α and HIF-2α of breast cancer cells when exposure to hypoxia (33, 34). This evidence concerns the gene HIF1A and breast carcinoma.