CASP8 and breast carcinoma: For instance, in breast cancer, DHA induced apoptosis and G0/G1 arrest by activating Bid, increased the expression of Bim, decreased the expression of Bcl-2, induced the translocation of Cyt C from the mitochondria to the cytosol, and increased the expression of caspase-8, and cleaved caspase-9 (43, 44).