For example, Zhang et al. found that nuclear AURKA acquired kinase-independent transactivating function to enhance breast cancer stem cell phenotype (32); PTTG1 promoted growth, endocrine therapy resistance of breast cancer (33–35); UBE2C post-transcriptionally upregulated by miR-196a enhanced proliferation of breast cancer cell (36). This evidence concerns the gene PTTG1 and breast carcinoma.