Reinstatement of IGFBP7 function utilizing the addition of recombinant IGFBP7 (rIGFBP7) causes programmed cell death in BRAF-positive cell lines derived from human melanoma, and systemically administered rIGFBP7 also has the capacity to suppress the growth of BRAF-positive tumors in xenograft mouse models (118). Here, BRAF is linked to melanoma.