IGFBP7 and Familial prostate cancer: The re-expression of IGFBP7 in a human prostate cancer cell line M12 led to a lengthening of cell doubling time, a decline in colony formation in soft agar, significant alteration in epithelial morphology, enhanced propensity to undergo apoptosis, and, finally, a reduction in the number and size of tumor formation in vivo (104).