IGFBP7 expression was mostly increased in CRC patients with Dukes' stages B and C compared to Dukes' stage A. Their findings suggest that plasma IGFBP7 levels do not reflect the local level of IGFBP7 in neoplastic tissue, and there is a significant difference regarding stage (of the neoplastic disease) and IGFBP7 expression. The gene discussed is IGFBP7; the disease is colorectal carcinoma.