Some studies have suggested that lumican gene expression in the tumor stroma is higher than that in tumor cells, and as an important intercellular signal molecule in the extracellular matrix, the lumican gene participates in many cellular biological processes and negatively regulates the occurrence and the progression of tumors mainly by affecting the formation of the extracellular matrix or the expression of tumor suppressor genes (22, 28–35). The gene discussed is LUM; the disease is neoplasm.