Based on The Cancer Genome Atlas (TCGA) dataset, the Gene Expression Omnibus (GEO) dataset, and quantitative real-time polymerase chain reaction (qRT-PCR), this study explored the relationship between LUM gene expression and the clinicopathological features of patients with GC and its prognostic significance to provide more evidence for its potential role as a prognostic biomarker in GC. Here, LUM is linked to gastric cancer.