Since we found that safe and effective immunity against ovarian tumors can be generated by AMHR2-ED-specific IgG, we generated a panel of monoclonal antibodies (mAbs) specific for recombinant human (rh) AMHR2-ED and characterized their binding and functional features to select a candidate mAb for use in human clinical trials focused on treatment of women with EOC. The gene discussed is AMHR2; the disease is ovarian neoplasm.