While we identified NNAT hypermethylation in OS employing a dedicated screen of childhood solid tumors, aberrant NNAT silencing has also been identified in human pituitary adenomas [15] and in human non-small-cell lung cancers [16] where NNAT transcriptional derepression was identified in mRNA expression screens employing RNAi-mediated or pharmacologically-mediated demethylation. Here, NNAT is linked to pituitary gland adenoma.