There was a trend toward reduced IFN-β and IFN-λ protein levels at 96 hpi in RV-infected BEC cultures from asthma and COPD donors, compared to healthy donors, although this was only statistically significant for IFN-λ in COPD donor cultures (Figures 2A,B). This evidence concerns the gene IFNB1 and chronic obstructive pulmonary disease.