Very recently, it was elucidated that infiltrating conventional DCs in the TME contribute to antitumor immune responses by selectively release of IFN-λ1 that stimulates Th1 differentiation and activation and effector CD8+ T-cell activation together with enhanced IFN-γ production through IL-12p70 production which as a result increases overall survival in human cancers (9). This evidence concerns the gene CD8A and cancer.