Lymphocytes including natural killer (NK) cells, CD8+ T cells and CD4+ helper T (Th) cells together with proinflammatory macrophages (M1) and dendritic cells from the anti-tumor immune responses while the heterogeneous population of myeloid-derived suppressor cells (MDSCs) and Foxp3+ regulatory T cells (Tregs) counteract tumor immunity. Here, CD4 is linked to neoplasm.