Such a macrophage polarization was also shown by hypoxic tumor exosomes enriched in CCL2, CSF1, TGF-β, macrophage migration inhibitory factor (MIF), ferritin heavy/light chain, endothelial monocyte-activating polypeptide 2 (EMAP2), and leukotriene A-4 hydrolase (195). Here, CCL2 is linked to neoplasm.