NOS2 and neoplasm: G-MDSCs inhibit CD8+ T cells through releasing ROS while M-MDSCs do it through secreting Arg1, iNOS, and ROS culminating in the impairment of ζ-chain expression, suppression of MHC class II expression, eliciting T-cell apoptosis, inhibition of Janus kinase (JAK) 3, and STAT5 in which all promote tumor progression (113).