Finally, there are tumors such as prostate (80–82) and lung cancer (83) as well as tumors that are auxotrophic for L-arg (these are not capable of re-synthesis of L-arg from citrulline due to the lack of expression of argininosuccinate synthetase-1, ASS-1), such as melanoma (84) and renal carcinoma (85, 86), where no correlation between ARG levels and survival has been found. This evidence concerns the gene ASS1 and male reproductive organ cancer.