Although the exact mechanisms remain unclear, evidence has shown LIGHT, when delivered as a fusion protein linked to a tumor vascular targeting peptide (VTP), can normalize intra-tumoral blood vessels via increased expression of the LTβR dependent pericyte contractile markers ICAM-1, VCAM-1, smooth muscle actin (SMA), calponin, and caldesmon (21–23). This evidence concerns the gene LTBR and neoplasm.