Furthermore, production of VEGF-protein family members downregulates effector lymphocyte attachment molecules such as intracellular adhesion molecules (ICAMs) and vascular cell adhesion molecules (VCAMs), supporting direct elimination of effector cells by T regulatory (Treg) cells through FAS/FASL interactions due to changes in the ratio of effector to suppressor cells, a problem that is further exacerbated by the tumor recruiting suppressive cells through the release of molecules such as CCL28 and CCL2 (Treg and myeloid derived suppressor cell chemo-attractants) (27–29). Here, VEGFA is linked to neoplasm.