M2 acts directly on the tumor cells and indirectly on the TME (50) by producing growth factors (Fibroblast Growth Factors, FGF; Vascular Endothelial Growth Factor, VEGF, and IL-6), matrix degrading enzymes and cytokines, thus inducing the neo-angiogenesis switch, tumor progression (37), tissue invasion and repair (51–54). This evidence concerns the gene VEGFA and neoplasm.