The observation that VAT PLZF+ γδ T cells promote the IL-33-Treg axis and thermogenesis under homeostatic conditions warrants the need for studies to explore the functions of PLZF+ γδ T cells in obese adipose tissue, whether they are lost during obesity, and whether IL-17 secretion by γδ T cells is impaired during obesity (196). The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.