↑ proportion in early obesity [H/M] (64, 65)  ↓ proportion in chronic obesity [H/M] (64, 65)  ↑ IFNγ and TNFα secretion [H/M] (65, 74, 76, 77)  ↑ mNK recruitment and expansion [H/M] (64, 65)  ↓ in NK degranulation and pro-inflammatory cytokine production during chronic obesity [H/M] (79)  ↑ myNK expansion in chronic obesity [H/M] (80). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.