NLRP3 and Insulin resistance: Recently, another unique population of B cell, aged adipose B cells (AABs), have been shown to accumulate in aged VAT, which are memory-like B cells that expand within the fat-associated lymphoid clusters (FALCs) in aged VAT in an NLRP3 dependent manner; depletion of these cells can improve insulin resistance in mice and reverse age-induced lipolytic dysfunction, and future work will need to assess triggers and targets regulating these cells function during aging (60, 156).