The VAT is enriched with iNKT cells which help maintain the adipose tissue microenvironment under homeostatic conditions by promoting IL-4-dependent M2-like macrophage polarization and sustaining Treg activity in an IL-10/IL-2-dependent manner; indeed, depletion of CD1d in adipocytes worsened inflammation and insulin resistance (190–192). The gene discussed is IL10; the disease is Insulin resistance.