During obesity, there is reportedly a decrease in the numbers of iNKT cells; furthermore, CD1d−/− mice deficient in iNKT cells display an insulin resistant phenotype even in the absence of a high fat diet and adipose inflammation, providing evidence for their protective function in the VAT during obesity (190, 203, 204). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.