In this regard, it has been proposed that altered GR gene regulation, which may be translated into diminished concentrations of GRs in different neural structures, more specifically hippocampal or hypothalamic GRs, may contribute to deficient feedback of the HPA system (63), which in turn may lead to the consequent alterations observed in patients suffering with depression or chronic anxiety disorders. This evidence concerns the gene BCL2A1 and depressive symptom measurement.