In this regard, it has been proposed that altered GR gene regulation, which may be translated into diminished concentrations of GRs in different neural structures, more specifically hippocampal or hypothalamic GRs, may contribute to deficient feedback of the HPA system (63), which in turn may lead to the consequent alterations observed in patients suffering with depression or chronic anxiety disorders. The gene discussed is BCL2A1; the disease is depressive disorder.