CRHR1 and post-traumatic stress disorder: In this respect, a recent study revealed a close relationship between the SNPs rs1360780 in the FK506-binding protein 5 (FKBP5) gene and rs17689918 in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and greater severity of the disease in posttraumatic stress disorder (PTSD) patients (60).