Noteworthy, TNF60, PIK3R1, TP53, PINK1, NRCAM, IL4R, ADRB1, PTEN, and RAPGEF2 show an association with SZ at different level of evidence (genetic association, expression, and literature) and, interestingly, IL4R and ADRB1 have been found also associated with MDD. The gene discussed is ADRB1; the disease is major depressive disorder.