PIK3R1 and major depressive disorder: Noteworthy, TNF60, PIK3R1, TP53, PINK1, NRCAM, IL4R, ADRB1, PTEN, and RAPGEF2 show an association with SZ at different level of evidence (genetic association, expression, and literature) and, interestingly, IL4R and ADRB1 have been found also associated with MDD.