To study this question, we compared lymphatic function in genetically obesity-resistant [myostatin (MSTN) knockout and BALB/c mice] and obesity-prone (C57BL/6J) mice that were fed on a HFD for prolonged periods of time (Garcia Nores et al., 2016). The gene discussed is MSTN; the disease is obesity due to melanocortin 4 receptor deficiency.