KCNK2 and prostate carcinoma: Furthermore, TREK-1 inhibits proliferation of neuronal stem cells, astrocytes, osteoblasts, Chinese hamster ovary cells, and neonatal cardiomyocytes (Hughes et al., 2006; Xi et al., 2011; Wang et al., 2012; Yang et al., 2014; Zhang et al., 2016), but increases the proliferation of prostate cancer cell lines (Voloshyna et al., 2008).